t(3;21)(q26;q22): a recurring chromosomal abnormality in therapy-related myelodysplastic syndrome and acute myeloid leukemia.

@article{Rubin1990t321q26q22AR,
  title={t(3;21)(q26;q22): a recurring chromosomal abnormality in therapy-related myelodysplastic syndrome and acute myeloid leukemia.},
  author={Charles M. Rubin and Richard A Larson and John Anastasi and Jane N. Winter and Maya Thangavelu and James W. Vardiman and Janet D. Rowley and Michelle M Le Beau},
  journal={Blood},
  year={1990},
  volume={76 12},
  pages={2594-8}
}
We have identified an identical reciprocal translocation between the long arms of chromosomes 3 and 21 with breakpoints at bands 3q26 and 21q22, [t(3;21)(q26;q22)], in the malignant cells from five adult patients with therapy-related myelodysplastic syndrome (t-MDS) or acute myeloid leukemia (t-AML). Primary diagnoses were Hodgkin's disease in two patients… CONTINUE READING