t(11;18)(q21;q21) of mucosa-associated lymphoid tissue lymphoma results from illegitimate non-homologous end joining following double strand breaks.

@article{Liu2004t1118q21q21OM,
  title={t(11;18)(q21;q21) of mucosa-associated lymphoid tissue lymphoma results from illegitimate non-homologous end joining following double strand breaks.},
  author={Hongxiang Liu and Rifat A. Hamoudi and Hongtao Ye and Agn{\`e}s Ruskon{\'e}-fourmestraux and A. Latif Dogan and Peter Gershon Isaacson and Ming-Qing Du},
  journal={British journal of haematology},
  year={2004},
  volume={125 3},
  pages={318-29}
}
t(11;18)(q21;q21) is the most frequent chromosomal aberration specifically associated with mucosa-associated lymphoid tissue (MALT) lymphoma. The translocation fuses the API2 gene to the MALT1 gene and generates a functional API2-MALT1 transcript. The breakpoint of the fusion gene is well characterized at the transcript level but poorly understood at the genomic level and the mechanism underlying the translocation is unknown. We identified the genomic breakpoint in 19 t(11;18)-positive MALT… CONTINUE READING