synthesis of sempervirine, a pentacyclic anhydronium indole alkaloid

@article{Chatterjee1996synthesisOS,
  title={synthesis of sempervirine, a pentacyclic anhydronium indole alkaloid},
  author={Alakananda Chatterjee and Arvind Sahu and Mukta Saha and Julie Banerji},
  journal={Monatshefte f{\"u}r Chemie / Chemical Monthly},
  year={1996},
  volume={127},
  pages={1259-1262}
}
SummarySempervirine (2,3,4,13-tetrahydro-1H-benz[g]indolo[2,3-a]quinolizin-6-ium,1) the pentacyclic anhydronium indole alkaloid ofGelsemium sempervirens Ait. f. (Loganiaceae), has been synthesized in three steps from hexahydroisochroman-3-one (6) and N-2-(3-indolyl)-ethylamine (tryptamine,7). The condensation product, N-2-(3-indolyl)-ethyl-2-(hydroxymethyl)-trans-hexahydrophenylacetamide (8) arising from6 and7 on double cyclization with phosphoryl chloride yielded the 3,4-dehydroyohimbane… CONTINUE READING
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