syn-Selective asymmetric cross-aldol reactions between aldehydes and glyoxylic acid derivatives catalyzed by an axially chiral amino sulfonamide.

Abstract

syn-Selective asymmetric cross-aldol reactions of aldehydes with tert-butyl glyoxylate and glyoxamide were realized by the use of an axially chiral amino sulfonamide (S)-1. The cross-aldol products obtained are densely functionalized and readily converted to synthetically useful and important chiral building blocks such as γ-lactone and γ-lactam.

DOI: 10.1039/c1cc14347f

Cite this paper

@article{Kano2011synSelectiveAC, title={syn-Selective asymmetric cross-aldol reactions between aldehydes and glyoxylic acid derivatives catalyzed by an axially chiral amino sulfonamide.}, author={Taichi Kano and Akira Noishiki and Ryu Sakamoto and Keiji Maruoka}, journal={Chemical communications}, year={2011}, volume={47 38}, pages={10626-8} }