sst2 Somatostatin receptor inhibits cell proliferation through Ras-, Rap1-, and B-Raf-dependent ERK2 activation.

@article{Lahlou2003sst2SR,
  title={sst2 Somatostatin receptor inhibits cell proliferation through Ras-, Rap1-, and B-Raf-dependent ERK2 activation.},
  author={Hicham Lahlou and Nathalie Saint-Laurent and J C Esteve and Alain Eych{\`e}ne and Lucien Pradayrol and St{\'e}phane Pyronnet and C. L. Susini},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 41},
  pages={
          39356-71
        }
}
The G protein-coupled sst2 somatostatin receptor is a critical negative regulator of cell proliferation. sstII prevents growth factor-induced cell proliferation through activation of the tyrosine phosphatase SHP-1 leading to induction of the cyclin-dependent kinase inhibitor p27Kip1. Here, we investigate the signaling molecules linking sst2 to p27Kip1. In Chinese hamster ovary-DG-44 cells stably expressing sst2 (CHO/sst2), the somatostatin analogue RC-160 transiently stimulates ERK2 activity… CONTINUE READING

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