sqv-3, -7, and -8, a set of genes affecting morphogenesis in Caenorhabditis elegans, encode enzymes required for glycosaminoglycan biosynthesis.

@article{Bulik2000sqv3A,
  title={sqv-3, -7, and -8, a set of genes affecting morphogenesis in Caenorhabditis elegans, encode enzymes required for glycosaminoglycan biosynthesis.},
  author={Dorota A Bulik and Guodong Wei and Hidenao Toyoda and Akiko Kinoshita-Toyoda and W R Waldrip and Jeffrey D Esko and Phillips W. Robbins and Scott B. Selleck},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 20},
  pages={10838-43}
}
sqv (squashed vulva) genes comprise a set of eight independent loci in Caenorhabditis elegans required zygotically for the invagination of vulval epithelial cells and maternally for normal oocyte formation and embryogenesis. Sequencing of sqv-3, sqv-7, and sqv-8 suggested a role for the encoded proteins in glycolipid or glycoprotein biosynthesis. Using a combination of in vitro analysis of SQV enzymatic activities, sqv(+)-mediated rescue of vertebrate cell lines, and biochemical… CONTINUE READING
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