spxA2, encoding a regulator of stress resistance in Bacillus anthracis, is controlled by SaiR, a new member of the Rrf2 protein family

@article{Nakano2014spxA2EA,
  title={spxA2, encoding a regulator of stress resistance in Bacillus anthracis, is controlled by SaiR, a new member of the Rrf2 protein family},
  author={Michiko M. Nakano and Wren Kominos-Marvell and Bhagyashree Sane and Yaldah Mohammad Nader and Skye M. Barendt and Marcus B. Jones and Peter Zuber},
  journal={Molecular Microbiology},
  year={2014},
  volume={94}
}
Spx, a member of the ArsC (arsenate reductase) protein family, is conserved in Gram‐positive bacteria, and interacts with RNA polymerase to activate transcription in response to toxic oxidants. In Bacillus anthracis str. Sterne, resistance to oxidative stress requires the activity of two paralogues, SpxA1 and SpxA2. Suppressor mutations were identified in spxA1 mutant cells that conferred resistance to hydrogen peroxide. The mutations generated null alleles of the saiR gene and resulted in… Expand
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