spRap1 and spRif1, recruited to telomeres by Taz1, are essential for telomere function in fission yeast

Abstract

Telomeres are essential for genome integrity. scRap1 (S. cerevisiae Rap1) directly binds to telomeric DNA and regulates telomere length and telomere position effect (TPE) by recruiting two different groups of proteins to its RCT (Rap1 C-terminal) domain. The first group, Rif1 and Rif2, regulates telomere length. The second group, Sir3 and Sir4, is involved… (More)
DOI: 10.1016/S0960-9822(01)00503-6

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