snoRNA, a Novel Precursor of microRNA in Giardia lamblia

  title={snoRNA, a Novel Precursor of microRNA in Giardia lamblia},
  author={Ashesh A. Saraiya and Ching Chiung Wang},
  journal={PLoS Pathogens},
  pages={219 - 230}
An Argonaute homolog and a functional Dicer have been identified in the ancient eukaryote Giardia lamblia, which apparently lacks the ability to perform RNA interference (RNAi). The Giardia Argonaute plays an essential role in growth and is capable of binding specifically to the m(7)G-cap, suggesting a potential involvement in microRNA (miRNA)-mediated translational repression. To test such a possibility, small RNAs were isolated from Giardia trophozoites, cloned, and sequenced. A 26-nucleotide… CONTINUE READING
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