smad2 and smad3 are required for mesendoderm induction by transforming growth factor-beta/nodal signals in zebrafish.

Abstract

The transforming growth factor-beta ligands Nodal, activin, and Vg1 play important roles in mesendoderm induction and patterning during vertebrate embryogenesis. These ligands are believed to transduce the signal through the receptor-activated transcription factors Smad2 and Smad3. However, the roles of smad2/3 genes in development of zebrafish embryos are… (More)

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