sigmaS, a major player in the response to environmental stresses in Escherichia coli: role, regulation and mechanisms of promoter recognition.

@article{Landini2014sigmaSAM,
  title={sigmaS, a major player in the response to environmental stresses in Escherichia coli: role, regulation and mechanisms of promoter recognition.},
  author={Paolo Landini and Thomas Egli and Johannes Wolf and St{\'e}phan Lacour},
  journal={Environmental microbiology reports},
  year={2014},
  volume={6 1},
  pages={1-13}
}
Bacterial cells often face hostile environmental conditions, to which they adapt by activation of stress responses. In Escherichia coli, environmental stresses resulting in significant reduction in growth rate stimulate the expression of the rpoS gene, encoding the alternative σ factor σ(S). The σ(S) protein associates with RNA polymerase, and through transcription of genes belonging to the rpoS regulon allows the activation of a 'general stress response', which protects the bacterial cell from… CONTINUE READING