sigma-1 receptors protect RGC-5 cells from apoptosis by regulating intracellular calcium, Bax levels, and caspase-3 activation.

@article{Tchedre2008sigma1RP,
  title={sigma-1 receptors protect RGC-5 cells from apoptosis by regulating intracellular calcium, Bax levels, and caspase-3 activation.},
  author={Kissaou T. Tchedre and Thomas Yorio},
  journal={Investigative ophthalmology & visual science},
  year={2008},
  volume={49 6},
  pages={
          2577-88
        }
}
PURPOSE sigma-1 Receptor ligands prevent neuronal death associated with glutamate excitotoxicity both in vitro and in vivo. However, the molecular mechanism of the neuroprotective effect remains to be elucidated. The present study was undertaken to determine whether sigma-1 receptor agonists provide neuroprotection by decreasing glutamate-induced calcium mobilization and preventing apoptotic gene expression. METHODS Cell death was measured by using a calcein-AM/propidium iodide cell-survival… CONTINUE READING
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