siSPOTR: a tool for designing highly specific and potent siRNAs for human and mouse

@inproceedings{Boudreau2013siSPOTRAT,
  title={siSPOTR: a tool for designing highly specific and potent siRNAs for human and mouse},
  author={Ryan L. Boudreau and Ryan M Spengler and Ray H. Hylock and Brandyn J. Kusenda and Heather A. Davis and David A. Eichmann and Beverly L. Davidson},
  booktitle={Nucleic acids research},
  year={2013}
}
RNA interference (RNAi) serves as a powerful and widely used gene silencing tool for basic biological research and is being developed as a therapeutic avenue to suppress disease-causing genes. However, the specificity and safety of RNAi strategies remains under scrutiny because small inhibitory RNAs (siRNAs) induce off-target silencing. Currently, the tools available for designing siRNAs are biased toward efficacy as opposed to specificity. Prior work from our laboratory and others' supports… CONTINUE READING
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