siRNA targeting LMP1-induced apoptosis in EBV-positive lymphoma cells is associated with inhibition of telomerase activity and expression.

@article{Mei2006siRNATL,
  title={siRNA targeting LMP1-induced apoptosis in EBV-positive lymphoma cells is associated with inhibition of telomerase activity and expression.},
  author={Yu-Ping Mei and Xiao-feng Zhu and Jun-min Zhou and He Huang and R. Q. Deng and Yi-xin Zeng},
  journal={Cancer letters},
  year={2006},
  volume={232 2},
  pages={189-98}
}
Epstein-Barr Virus (EBV) is closely associated with B cell malignancies. However, whether EBV appears to be absolutely required for cell proliferation and survival in lymphoma cells is still unknown. In this study, small interfering RNA (siRNA) targeting LMP1 was employed to investigate the effect of LMP1 on cell proliferation in EBV-positive lymphoblastoid B-cell line. A plasmid stable encoding 21-nt small RNA specifically and efficiently interfering LMP1 was constructed, resulting in a… CONTINUE READING