siRNA repositioning for guide strand selection by human Dicer complexes.

@article{Noland2011siRNARF,
  title={siRNA repositioning for guide strand selection by human Dicer complexes.},
  author={Cameron Ladd Noland and Enbo Ma and Jennifer A. Doudna},
  journal={Molecular cell},
  year={2011},
  volume={43 1},
  pages={
          110-21
        }
}
The human ribonuclease Dicer and its double-stranded RNA (dsRNA)-binding protein (dsRBP) partners TRBP and PACT play important roles in the biogenesis of regulatory RNAs. Following dicing, one dsRNA product strand is preferentially assembled into an RNA-induced silencing complex (RISC). The mechanism of strand selection in humans and the possible role of Dicer in this process remain unclear. Here we demonstrate that dsRNAs undergo significant repositioning within Dicer complexes following… CONTINUE READING
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