siRNA nanoparticle functionalization of nanostructured scaffolds enables controlled multilineage differentiation of stem cells.

Abstract

The creation of complex tissues and organs is the ultimate goal in tissue engineering. Engineered morphogenesis necessitates spatially controlled development of multiple cell types within a scaffold implant. We present a novel method to achieve this by adhering nanoparticles containing different small-interfering RNAs (siRNAs) into nanostructured scaffolds… (More)
DOI: 10.1038/mt.2010.166

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