siRNA-mediated silencing of survivin inhibits proliferation and enhances etoposide chemosensitivity in acute myeloid leukemia cells.

Abstract

BACKGROUND Overexpression of survivin, a known inhibitor of apoptosis, is associated with tumor progression and drug resistance in numerous malignancies, including leukemias. The aim of this study was to investigate the effect of a specific survivin small interference RNA (siRNA) on proliferation and the sensitivity of HL-60 acute myeloid leukemia (AML… (More)

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@article{Karami2013siRNAmediatedSO, title={siRNA-mediated silencing of survivin inhibits proliferation and enhances etoposide chemosensitivity in acute myeloid leukemia cells.}, author={Hadi Karami and Behzad Baradaran and Ali Akbar Nasr Esfahani and Mehrdad Asghari Estiar and Mohammad Naghavi-Behzad and Masoud Sakhinia and Ebrahim Sakhinia}, journal={Asian Pacific journal of cancer prevention : APJCP}, year={2013}, volume={14 12}, pages={7719-24} }