siRNA-mediated silencing of Wnt5a regulates inflammatory responses in atherosclerosis through the MAPK/NF-κB pathways.

@article{Yang2014siRNAmediatedSO,
  title={siRNA-mediated silencing of Wnt5a regulates inflammatory responses in atherosclerosis through the MAPK/NF-κB pathways.},
  author={Lei Yang and Yingjie Chu and Yuhang Wang and Xiangmei Zhao and Wenke Xu and Peirong Zhang and Xiaoyu Liu and Shujuan Dong and Wenqi He and Chuan-yu Gao},
  journal={International journal of molecular medicine},
  year={2014},
  volume={34 4},
  pages={1147-52}
}
Previous studies have demonstrated that the aberrant expression of Wnt5a occurs in atherosclerotic lesions. However, the precise role of Wnt5a in the pathogenesis of atherosclerosis remains largely unknown. The present study was undertaken to determine whether the RNA interference of Wnt5a in vivo by adenovirus (Ad)-mediated small interfering RNA (siRNA) transfection is capable of inhibiting the progression of atherosclerosis. Recombinant adenovirus carrying siRNA targeting Wnt5a (Ad-Wnt5a… CONTINUE READING

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