siRNA-mediated knockdown of Pdcd4 expression causes upregulation of p21(Waf1/Cip1) expression

@article{Bitomsky2008siRNAmediatedKO,
  title={siRNA-mediated knockdown of Pdcd4 expression causes upregulation of p21(Waf1/Cip1) expression},
  author={Nadja Bitomsky and Nils Wethkamp and Rajeshwari Marikkannu and K -H Klempnauer},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={4820-4829}
}
The transformation suppressor gene, programmed cell death gene 4 (Pdcd4), inhibits tumor-promoter-mediated transformation of mouse keratinocytes and has been implicated as a tumor suppressor gene in the development of human cancer. The Pdcd4 protein interacts with translation initiation factors eIF4A and eIF4G and binds to RNA, suggesting that it might be involved in regulating protein translation or other aspects of RNA metabolism. To study the function of Pdcd4 in more detail, we have… CONTINUE READING

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The transformation suppressor gene , programmed cell death gene 4 ( Pdcd4 ) , inhibits tumor - promoter - mediated transformation of mouse keratinocytes and has been implicated as a tumor suppressor gene in the development of human cancer .
Our results provide the first evidence that Pdcd4 is important role in the DNA - damage response and suggest that low levels of Pdcd4 expression observed in certain tumor cells contribute to tumorigenesis by affecting the fate of DNA - damaged cells .
The transformation suppressor gene , programmed cell death gene 4 ( Pdcd4 ) , inhibits tumor - promoter - mediated transformation of mouse keratinocytes and has been implicated as a tumor suppressor gene in the development of human cancer .
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