siRNA delivery systems for cancer treatment.

  title={siRNA delivery systems for cancer treatment.},
  author={Y B Oh and Tae Gwan Park},
  journal={Advanced drug delivery reviews},
  volume={61 10},
With increasing knowledge on the molecular mechanisms of endogenous RNA interference, small interfering RNAs (siRNAs) have been emerging as innovative nucleic acid medicines for treatment of incurable diseases such as cancers. Although several siRNA candidates for the treatment of ocular and respiratory diseases are undergoing clinical trials, there are challenges inherent in the further development of siRNAs for anti-cancer therapeutics, because systemic administration will be required in most… CONTINUE READING
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