siRNA-based topical microbicides targeting sexually transmitted infections.

  title={siRNA-based topical microbicides targeting sexually transmitted infections.},
  author={Joseph A Katakowski and Deborah Palliser},
  journal={Current opinion in molecular therapeutics},
  volume={12 2},
Sexually transmitted infections (STIs) are a major cause of morbidity and mortality worldwide. Although a vaccine is available for HPV, no effective vaccines exist for the HIV-1 and HSV-2 viral pathogens, and there are no cures for these infections. Furthermore, recent setbacks in clinical trials, such as the failure of the STEP trial to prevent HIV-1 infection, have emphasized the need to develop alternative approaches to interrupt the transmission of these pathogens. One alternative strategy… CONTINUE READING