siRNA-Based Targeting of Cyclin E Overexpression Inhibits Breast Cancer Cell Growth and Suppresses Tumor Development in Breast Cancer Mouse Model

@inproceedings{Liang2010siRNABasedTO,
  title={siRNA-Based Targeting of Cyclin E Overexpression Inhibits Breast Cancer Cell Growth and Suppresses Tumor Development in Breast Cancer Mouse Model},
  author={Yulong Liang and Hong Gao and Shiaw-Yih Lin and John A. Goss and Francis Charles Brunicardi and Kaiyi Li},
  booktitle={PloS one},
  year={2010}
}
  • Yulong Liang, Hong Gao, +3 authors Kaiyi Li
  • Published in PloS one 2010
  • Biology, Medicine
  • Cyclin E is aberrantly expressed in many types of cancer including breast cancer. High levels of the full length as well as the low molecular weight isoforms of cyclin E are associated with poor prognosis of breast cancer patients. Notably, cyclin E overexpression is also correlated with triple-negative basal-like breast cancers, which lack specific therapeutic targets. In this study, we used siRNA to target cyclin E overexpression and assessed its ability to suppress breast cancer growth in… CONTINUE READING

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