shRNA targeting long non-coding RNA CCAT2 controlled by tetracycline-inducible system inhibits progression of bladder cancer cells

@inproceedings{Li2016shRNATL,
  title={shRNA targeting long non-coding RNA CCAT2 controlled by tetracycline-inducible system inhibits progression of bladder cancer cells},
  author={Jianfa Li and Chengle Zhuang and Yuchen Liu and Ming-wei Chen and Qing Zhou and Zhicong Chen and Anbang He and Guo-Ping Zhao and Yinglu Guo and Hanwei Wu and Zhi-Ming Cai and Weiren Huang},
  booktitle={Oncotarget},
  year={2016}
}
Recent reports show that long non-coding RNAs (lncRNAs) are emerging as significant functional regulators in the development of tumors, including bladder cancer. Here, we found that CCAT2 was upregulated in bladder cancer tissues and cell lines. Through the statistical analyses, we also found that the high expression level of CCAT2 was positively correlated with histological grade and TNM stage of bladder cancer. Further experimental results revealed that knockdown of CCAT2 could decrease cell… CONTINUE READING
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