shRNA library screening identifies nucleocytoplasmic transport as a mediator of BCR-ABL1 kinase-independent resistance.

Abstract

The mechanisms underlying tyrosine kinase inhibitor (TKI) resistance in chronic myeloid leukemia (CML) patients lacking explanatory BCR-ABL1 kinase domain mutations are incompletely understood. To identify mechanisms of TKI resistance that are independent of BCR-ABL1 kinase activity, we introduced a lentiviral short hairpin RNA (shRNA) library targeting… (More)
DOI: 10.1182/blood-2014-08-588855

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@article{Khorashad2015shRNALS, title={shRNA library screening identifies nucleocytoplasmic transport as a mediator of BCR-ABL1 kinase-independent resistance.}, author={Jamshid S Khorashad and Anna M. Eiring and Clinton C. Mason and Kevin C. Gantz and Amber D. Bowler and Hannah M. Redwine and Fan Yu and Ira Lignugaris Kraft and Anthony D. Pomicter and Kimberly R. Reynolds and Anthony J Iovino and Matthew S. Zabriskie and William L. Heaton and Srinivas Kiran Tantravahi and Michael G. Kauffman and Sharon Shacham and Alex A. Chenchik and Kyle Bonneau and Katharine S. Ullman and Thomas H. O'Hare and Michael W. N. Deininger}, journal={Blood}, year={2015}, volume={125 11}, pages={1772-81} }