secErbB4-26/549 antagonizes ligand-induced ErbB4 tyrosine phosphorylation.

  title={secErbB4-26/549 antagonizes ligand-induced ErbB4 tyrosine phosphorylation.},
  author={Jennifer L. Gilmore and David J. Riese},
  journal={Oncology research},
  volume={14 11-12},
ErbB4 is a member of the ErbB family of receptor tyrosine kinases. Because of a paucity of appropriate pharmacologic tools, little is known about ErbB4 functions in vivo. In response to this need, we hypothesized that a recombinant form of the extracellular domain of ErbB4 would antagonize ligand-induced receptor tyrosine phosphorylation and subsequent downstream signaling and could be used to probe ErbB4 function. Indeed, we show here that one such ErbB4 protein, secErbB4-26/549, is a potent… CONTINUE READING