scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair.

@article{Biedermann1991scidMI,
  title={scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair.},
  author={K. A. Biedermann and Jirong Sun and Amato J. Giaccia and Liana M. Tosto and Janice M. Y. Brown},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 4},
  pages={1394-7}
}
C.B-17 severe combined immunodeficient (scid) mice carry the scid mutation and are severely deficient in both T cell- and B cell-mediated immunity, apparently as a result of defective V(D)J joining of the immunoglobulin and T-cell receptor gene elements. In the present studies, we have defined the tissue, cellular, and molecular basis of another characteristic of these mice: their hypersensitivity to ionizing radiation. Bone marrow stem cells, intestinal crypt cells, and epithelial skin cells… CONTINUE READING
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