sMEK1 enhances gemcitabine anti-cancer activity through inhibition of phosphorylation of Akt/mTOR

@article{Byun2012sMEK1EG,
  title={sMEK1 enhances gemcitabine anti-cancer activity through inhibition of phosphorylation of Akt/mTOR},
  author={Hyun-Jung Byun and Boh-Ram Kim and Richard Y Yoo and Sang Yoon Park and Seung Bae Rho},
  journal={Apoptosis},
  year={2012},
  volume={17},
  pages={1095-1103}
}
Recently, we reported that sMEK1 is down-regulated in cancer cells and tissues, and that it enhances the pro-proliferative effect as a novel pro-apoptotic protein. However, the biological mechanism of the sMEK1 tumor suppressor in the cellular signal pathway has not been well understood. In our current work, we examined whether sMEK1 could promote the cytotoxic activity of gemcitabine in the human ovarian carcinoma system. Initially, we attempted to use a treatment of gemcitabine traditional… CONTINUE READING

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