sFas and sFas Ligand and Pediatric Sepsis-Induced Multiple Organ Failure Syndrome

@article{Doughty2002sFasAS,
  title={sFas and sFas Ligand and Pediatric Sepsis-Induced Multiple Organ Failure Syndrome},
  author={Lesley A Doughty and Robert B. Clark and Sandra S. Kaplan and Howell Sasser and Joseph Carcillo},
  journal={Pediatric Research},
  year={2002},
  volume={52},
  pages={922-927}
}
The Fas-Fas ligand system is important for apoptosis of activated immune cells. Perturbation of this system occurs in diseases with dysregulated inflammation. Increased soluble Fas (sFas) occurs in systemic inflammatory response syndrome (SIRS) and can block apoptosis. Increased shedding of FasL (sFasL) occurs in viral infection and hepatitis. Although dysregulated inflammation is associated with sepsis-induced multiple organ failure (MOF) in children, a role for Fas has not been established… CONTINUE READING

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