s-Ethyl cysteine, an amino acid derivative, attenuated cisplatin induced nephrotoxicity

@article{Kuo2020sEthylCA,
  title={s-Ethyl cysteine, an amino acid derivative, attenuated cisplatin induced nephrotoxicity},
  author={H L Kuo and Mei-chin Mong and Hung-Chih Chen and Zhi‐hong Wang and Mei-chin Yin},
  journal={Amino Acids},
  year={2020},
  volume={52},
  pages={1181 - 1190}
}
Renal protection from s-ethyl cysteine (SEC) against cisplatin (CP)-induced inflammatory and oxidative injury was examined. Mice were divided into five groups: normal group, 0.25% SEC group, CP group, 0.125% SEC + CP group, 0.25% SEC + CP group. After 2 weeks supplementation, mice of CP and SEC + CP groups received CP treatment. H&E stain showed that CP caused infiltration of inflammatory cells and necrosis of tubular cells. SEC pre-treatments attenuated CP-induced inflammatory injury and… 

Cisplatin-Induced Kidney Toxicity: Potential Roles of Major NAD+-Dependent Enzymes and Plant-Derived Natural Products

The underlying mechanisms of cisplatin kidney injury are reviewed in the context of NAD+-dependent redox enzymes including mitochondrial complex I, NAD kinase, CD38, sirtuins, poly-ADP ribosylase polymerase, and nicotinamide nucleotide transhydrogenase and their potential contributing roles in the amelioration of cisPlatin-induced kidney injury conferred by natural products derived from plants.

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