s-Ethyl cysteine, an amino acid derivative, attenuated cisplatin induced nephrotoxicity
@article{Kuo2020sEthylCA, title={s-Ethyl cysteine, an amino acid derivative, attenuated cisplatin induced nephrotoxicity}, author={H L Kuo and Mei-chin Mong and Hung-Chih Chen and Zhi‐hong Wang and Mei-chin Yin}, journal={Amino Acids}, year={2020}, volume={52}, pages={1181 - 1190} }
Renal protection from s-ethyl cysteine (SEC) against cisplatin (CP)-induced inflammatory and oxidative injury was examined. Mice were divided into five groups: normal group, 0.25% SEC group, CP group, 0.125% SEC + CP group, 0.25% SEC + CP group. After 2 weeks supplementation, mice of CP and SEC + CP groups received CP treatment. H&E stain showed that CP caused infiltration of inflammatory cells and necrosis of tubular cells. SEC pre-treatments attenuated CP-induced inflammatory injury and…
One Citation
Cisplatin-Induced Kidney Toxicity: Potential Roles of Major NAD+-Dependent Enzymes and Plant-Derived Natural Products
- Biology, ChemistryBiomolecules
- 2022
The underlying mechanisms of cisplatin kidney injury are reviewed in the context of NAD+-dependent redox enzymes including mitochondrial complex I, NAD kinase, CD38, sirtuins, poly-ADP ribosylase polymerase, and nicotinamide nucleotide transhydrogenase and their potential contributing roles in the amelioration of cisPlatin-induced kidney injury conferred by natural products derived from plants.
References
SHOWING 1-10 OF 36 REFERENCES
Protective and alleviative effects from 4 cysteine-containing compounds on ethanol-induced acute liver injury through suppression of oxidation and inflammation.
- MedicineJournal of food science
- 2007
Results support that SEC and SPC could provide both preventive and alleviative effects against alcohol-induced hepatotoxicity through suppression of oxidation and inflammation.
Amelioration of cisplatin nephrotoxicity by genetic or pharmacologic blockade of prostaglandin synthesis.
- Biology, ChemistryKidney international
- 2011
Results suggest the activation of COX-2/mPGES-1 pathway in renal parenchymal cells may selectively mediate cisplatin-induced renal injury and offer a novel therapeutic target for management of the adverse effect of cisPlatin chemotherapy.
Five cysteine-containing compounds delay diabetic deterioration in Balb/cA mice.
- Biology, MedicineThe Journal of nutrition
- 2004
via their antioxidant activities, the 5 compounds effectively improved glycemic control, delayed oxidation damage, downregulated inflammatory cytokines, and enhanced anticoagulant activity in diabetic mice, and support the multiple roles of these agents as potential protective agents for delaying diabetic deterioration.
Sinapic acid modulates Nrf2/HO-1 signaling pathway in cisplatin-induced nephrotoxicity in rats.
- Biology, ChemistryBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- 2017
Antiinflammatory and antifibrogenic effects of s-ethyl cysteine and s-methyl cysteine in the kidney of diabetic mice.
- Medicine, BiologyMolecular nutrition & food research
- 2007
Results showed that the intake of SEC or SMC alleviated body weight loss and urine output, as well as markedly decreased plasma blood urea nitrogen and creatinine clearance in diabetic mice, and the supplement might be helpful for the prevention or treatment of diabetic kidney diseases.
Abrogation of cisplatin-induced hepatotoxicity in mice by xanthorrhizol is related to its effect on the regulation of gene transcription.
- Biology, ChemistryToxicology and applied pharmacology
- 2004
Melatonin suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2/HO-1 pathway
- BiologyNutrition & Metabolism
- 2013
Melatonin attenuates cisplatin-induced nephrotoxicity possibly by modulating Nrf2/HO-1 signaling, and this study suggests that the mechanism of the protective effect of melatonin against cisplarin-induced renal damage is still essentially unknown.
Enzymatic studies of cisplatin induced oxidative stress in hepatic tissue of rats.
- BiologyEuropean journal of pharmacology
- 2006
Antiglycative and anti-VEGF effects of s-ethyl cysteine and s-propyl cysteine in kidney of diabetic mice.
- Medicine, BiologyMolecular nutrition & food research
- 2008
The present study suggests the supplement of SEC or SPC might be helpful for the prevention or treatment of diabetic kidney diseases via alleviating renal glycative injury.
Role of oxidative and nitrosative stress in cisplatin-induced nephrotoxicity.
- BiologyExperimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
- 2009