rs5848 variant of progranulin gene is a risk of Alzheimer's disease in the Taiwanese population.

Abstract

Progranulin is the precursor of granulins, and its downregulation may lead to neurodegeneration. The single-nucleotide polymorphism rs5848 increases the risk of Alzheimer's disease (AD). We explored the association between alleles of rs5848 and the risk of AD in the Taiwanese population. The frequency of the homozygous TT genotype (16.4 vs. 10.0%) increased… (More)
DOI: 10.1159/000322538

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