rs2735383, located at a microRNA binding site in the 3’UTR of NBS1, is not associated with breast cancer risk

  title={rs2735383, located at a microRNA binding site in the 3’UTR of NBS1, is not associated with breast cancer risk},
  author={Jingjing Liu and Ivona Lon{\vc}ar and J Margriet Coll{\'e}e and Manjeet K. Bolla and Joe G Dennis and Kyriaki Michailidou and Qin Wang and Irene L Andrulis and M{\^o}nica Palos Barile and Matthias Wilhelm Beckmann and Sabine Behrens and Javier Ben{\'i}tez and Carl Blomqvist and Bram Boeckx and Natalia V. Bogdanova and Stig Egil Bojesen and Hiltrud Brauch and Paul Brennan and Hermann Brenner and Annegien Broeks and Barbara Burwinkel and Jenny Chang-Claude and Shi Yao Chen and Georgia Chenevix-Trench and Ching Yu Cheng and Ji-Yeob Choi and Fergus J. Couch and Angie M. Cox and Simon S. Cross and Katarina Cuk and Kamila Czene and Thilo D{\"o}rk and Isabel Dos-Santos-Silva and Peter A. Fasching and Jonine D Figueroa and Henrik Flyger and Montserrat Garc{\'i}a-Closas and Graham G. Giles and Gordon Glendon and Mark S. Goldberg and Anna Gonz{\'a}lez-Neira and Pascal Gu{\'e}nel and Christopher A. Haiman and Ute Hamann and Steven N. Hart and Mikael Hartman and Sigrid Hatse and John L Hopper and Hidemi Ito and Anna Jakubowska and Maria Kabisch and Daehee Kang and V M Kosma and Vessela N. Kristensen and Lo{\"i}c Le Marchand and Eunjung Lee and Jingmei Li and Artitaya Lophatananon and Jan Lubinski and Arto J Mannermaa and Keitaro Matsuo and Roger L Milne and Susan L. Neuhausen and Heli Nevanlinna and Nick Orr and Jos{\'e} Ignacio Arias P{\'e}rez and Julian Peto and Thomas C. Putti and Katri Pylk{\"a}s and Paolo Radice and Suleeporn Sangrajrang and Elinor J Sawyer and Marjanka K Schmidt and Andreas Schneeweiss and Chen-yang Shen and Martha J. Shrubsole and Xiao-Ou Shu and Jacques Simard and Melissa C. Southey and Anthony J Swerdlow and Soo Hwang Teo and Daniel C. Tessier and Somchai Thanasitthichai and Ian P. M. Tomlinson and Diana Torres and Th{\'e}r{\`e}se Truong and Chiu-chen Tseng and Celine M. Vachon and Robert Winqvist and Anna H Wu and Drakoulis Yannoukakos and Wei Zheng and Per Hall and Alison M. Dunning and Douglas F. Easton and Maartje J. Hooning and Ans M. W. van den Ouweland and John W. M. Martens and Antoinette Hollestelle and Kristine Kleivi Sahlberg and Lars Ottestad and Rolf K{\aa}resen and Anita Langer{\o}d and Ellen Schlichting and Marit Muri Holmen and Toril Sauer and Vilde Drageset Haakensen and Olav Engebr{\aa}ten and Bj{\o}rn Naume and Cecile E. Kiserud and Kristin Valborg Reinertsen and {\AA}slaug Helland and Margit L. H. Riis and Ida R. K. Bukholm and P E L{\o}nning and Anne-Lise B{\o}rresen-Dale and Grethe I. Grenaker Aln{\ae}s},
  booktitle={Scientific reports},
NBS1, also known as NBN, plays an important role in maintaining genomic stability. Interestingly, rs2735383 G > C, located in a microRNA binding site in the 3'-untranslated region (UTR) of NBS1, was shown to be associated with increased susceptibility to lung and colorectal cancer. However, the relation between rs2735383 and susceptibility to breast cancer is not yet clear. Therefore, we genotyped rs2735383 in 1,170 familial non-BRCA1/2 breast cancer cases and 1,077 controls using PCR-based… CONTINUE READING


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