rs15869 at miRNA binding site in BRCA2 is associated with breast cancer susceptibility

@article{Cao2016rs15869AM,
  title={rs15869 at miRNA binding site in BRCA2 is associated with breast cancer susceptibility},
  author={Jingjing Cao and Cheng-lin Luo and Rui Yan and Rui Peng and Kaijuan Wang and Peng Wang and Hua Ye and Chunhua Song},
  journal={Medical Oncology},
  year={2016},
  volume={33},
  pages={1-12}
}
BRCA1 and BRCA2 mutations confer an increased lifetime risk of breast cancer; however, the associations of microRNA (miRNA) binding site single nucleotide polymorphisms (SNPs) in 3′ untranslated region (3′-UTR) of BRCA1 and BRCA2 with breast cancer (BC) risk were rarely reported. In this case–control study (498 BC patients and 498 matched controls), three SNPs (rs8176318, rs12516 and rs15869) were selected in the 3′-UTR of BRCA1 and BRCA2 genes, which were within miRNA-binding seed regions and… 
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