rpS6 regulates blood-testis barrier dynamics through Akt-mediated effects on MMP-9.

  title={rpS6 regulates blood-testis barrier dynamics through Akt-mediated effects on MMP-9.},
  author={Ka-Wai Mok and Dolores D. Mruk and C. Yan Cheng},
  journal={Journal of cell science},
  volume={127 Pt 22},
Mammalian target of rapamycin complex 1 (mTORC1) is an emerging regulator of blood-tissue barriers that utilizes ribosomal protein S6 (rpS6) as the downstream signaling molecule. To explore the role of rpS6 in blood-testis barrier (BTB) function, a constitutively active quadruple rpS6 phosphomimetic mutant was constructed in mammalian expression vector and overexpressed in Sertoli cells cultured in vitro that mimicked the BTB in vivo. Using this quadruple phosphomimetic mutant, phosphorylated… CONTINUE READING


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