rhBMP-collagen sponges as osteoinductive devices: effects of in vitro sponge characteristics and protein pI on in vivo rhBMP pharmacokinetics.

@article{Uluda1999rhBMPcollagenSA,
  title={rhBMP-collagen sponges as osteoinductive devices: effects of in vitro sponge characteristics and protein pI on in vivo rhBMP pharmacokinetics.},
  author={Hasan Uludağ and Wolfgang Friess and Derek A. Williams and Terence Porter and Gregg A. Timony and Darren D'Augusta and Camille Bond Blake and Ruth Palmer and Ben Biron and John Wozney},
  journal={Annals of the New York Academy of Sciences},
  year={1999},
  volume={875},
  pages={369-78}
}
Osteoinductive devices, comprised of biodegradable collagen scaffolds and recombinant human Bone Morphogenetic Proteins (rhBMPs), are being currently pursued for local bone induction. To better understand the biological performance of such devices, we have carried out a series of studies to investigate the effects of sponge properties and protein structural features on the pharmacokinetics of implanted rhBMPs. The results indicated little dependence of the rhBMP-2 pharmacokinetics on the in… CONTINUE READING

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