rhBMP-2 modulation of gene expression in infected segmental bone defects.

@article{Brick2009rhBMP2MO,
  title={rhBMP-2 modulation of gene expression in infected segmental bone defects.},
  author={Katherine E Brick and Xinqian Chen and Jamie Lohr and Andrew H. Schmidt and Louis S. Kidder and William Lew},
  journal={Clinical orthopaedics and related research},
  year={2009},
  volume={467 12},
  pages={3096-103}
}
The osteoinductive capability of BMPs appears diminished in the setting of acute infection. We applied rhBMP-2 to a segmental defect in a rat femur and measured the expression of key bone formation genes in the presence of acute infection. Types I and II collagen, osteocalcin, and BMP Type II receptor mRNA expression were characterized in 72 Sprague-Dawley rats, which received either bovine collagen carrier with 200 mug rhBMP-2 plus Staphylococcus aureus, carrier with bacteria only, carrier… CONTINUE READING