rhBMP-2 has adverse effects on human oral carcinoma cell lines in vivo.

  title={rhBMP-2 has adverse effects on human oral carcinoma cell lines in vivo.},
  author={Natalia A Kokorina and James S Lewis and Stanislav O. Zakharkin and Paul H Krebsbach and Brian Nussenbaum},
  journal={The Laryngoscope},
  volume={122 1},
OBJECTIVES/HYPOTHESIS To establish the relevance of the bone morphogenetic protein (BMP) signaling pathway in human oral squamous cell carcinoma (OSCCA) cell lines and determine if there is a biologic impact of stimulating this pathway with recombinant human (rh) BMP-2. STUDY DESIGN In vitro laboratory investigations and in vivo analysis using an orthotopic animal model for oral cancer. METHODS Gene expression profiles for BMP-2 and components of the BMP-signaling pathway were determined… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 13 extracted citations


Publications referenced by this paper.
Showing 1-10 of 39 references

package insert

  • INFUSE Bone Graf
  • Available at: https://www. infusebonegraft.com…
  • 2012
1 Excerpt

Bone morphogenetic protein-2/4 and bone morphogenetic protein receptor type IA expression in metastatic and nonmetastatic oral squamous cell carcinoma

  • AF Soares, RL Xavier, MC daCosta Miguel
  • Am J Otolaryngol
  • 2010
1 Excerpt

Similar Papers

Loading similar papers…