rh-erythropoietin stimulates immature reticulocyte release in man.

  title={rh-erythropoietin stimulates immature reticulocyte release in man.},
  author={Attila L Major and Christian R. K. D. Bauer and Christian Breymann and Albert Huch and Renate Huch},
  journal={British journal of haematology},
  volume={87 3},
The pharmacodynamics of single intravenous dosing with recombinant human erthropoietin (rhEPO) was investigated in eight healthy volunteers (150 U/kg, n = 2; 300 U/kg, n = 6) with respect to reticulocyte subdivisions (by fluorescence flow cytometry) and serum ferritin over 6.5 d. The present study shows that bolus rhEPO injection produces an immediate release of high and middle fluorescence (immature) reticulocytes with a high RNA content from the marrow into the circulation, whereas the low… CONTINUE READING

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