rev protein of human immunodeficiency virus type 1 affects the stability and transport of the viral mRNA.

@article{Felber1989revPO,
  title={rev protein of human immunodeficiency virus type 1 affects the stability and transport of the viral mRNA.},
  author={Barbara K Felber and Margarita Hadzopoulou-Cladaras and C Cladaras and Terry Copeland and George N Pavlakis},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 5},
  pages={1495-9}
}
rev (trs/art) is an essential human immunodeficiency virus type 1 (HIV-1) regulatory protein. rev increases the levels of the gag- and env-producing mRNAs via a cis-acting element in the env region of HIV-1, named rev-responsive element. Our results show that rev increases the stability of the unspliced viral mRNA, while it does not affect the stability of the multiply spliced viral mRNAs that do not contain the rev-responsive element. The study of mutated proviral constructs producing mRNA… CONTINUE READING

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