repgenHMM: a dynamic programming tool to infer the rules of immune receptor generation from sequence data


MOTIVATION The diversity of the immune repertoire is initially generated by random rearrangements of the receptor gene during early T and B cell development. Rearrangement scenarios are composed of random events-choices of gene templates, base pair deletions and insertions-described by probability distributions. Not all scenarios are equally likely, and the… (More)
DOI: 10.1093/bioinformatics/btw112

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