relA is required for actinomycin production in Streptomyces antibioticus.

@article{Hoyt1999relAIR,
  title={relA is required for actinomycin production in Streptomyces antibioticus.},
  author={Suzannah M Hoyt and George Hilton Jones},
  journal={Journal of bacteriology},
  year={1999},
  volume={181 12},
  pages={
          3824-9
        }
}
The relA gene from Streptomyces antibioticus has been cloned and sequenced. The gene encodes a protein with an Mr of 93,653, which is 91% identical to the corresponding protein from Streptomyces coelicolor. Disruption of S. antibioticus relA produces a strain which grows significantly more slowly on actinomycin production medium than the wild type or a disruptant to which the intact relA gene was restored. Moreover, the disruptant was unable to accumulate ppGpp to the levels observed during the… CONTINUE READING

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Comparative genomics and evolution of genes encoding bacterial (p)ppGpp synthetases/hydrolases (the Rel, RelA and SpoT proteins).

  • Journal of molecular microbiology and biotechnology
  • 2001
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