recA-independent DNA recombination between repetitive sequences: mechanisms and implications.

@article{Bi1996recAindependentDR,
  title={recA-independent DNA recombination between repetitive sequences: mechanisms and implications.},
  author={X Bi and L. F. Liu},
  journal={Progress in nucleic acid research and molecular biology},
  year={1996},
  volume={54},
  pages={
          253-92
        }
}
  • X. Bi, L. Liu
  • Published 1996
  • Biology, Medicine
  • Progress in nucleic acid research and molecular biology
Publisher Summary This chapter discusses the distinct features of recA -independent recombination among repetitive sequences in bacteria, with special emphasis on replicational models and their implications in related processes such as genome rearrangement and gene amplification in eukaryotic cells. In Escherichia coli , general (or homologous) recombination typically involves extensive stretches of sequence homology and is dependent on the RecA protein and other recombination functions. Site… Expand
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A model for recA-independent crossovers between replicating sister strands, which can also explain deletion or amplification of repeated sequences is proposed; it is suggested that this process may be initiated as post-replicational DNA repair; subsequent strand misalignment at repeated sequences leads to genetic rearrangements. Expand
Specific stimulation of recA-independent plasmid recombination by a DNA sequence at a distance.
TLDR
The results provide an example that recA-independent recombination can be influenced by DNA sequences at a distance and a neutral sequence of comparable size was able to substitute for the sequence in influencing recombination. Expand
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  • X. Bi, L. Liu
  • Biology, Medicine
  • Journal of molecular biology
  • 1994
TLDR
It is concluded that increasing the distance separating the homologous regions preferentially inhibits the recA-independent recombination and on the other hand, shortening of the homology preferentialially inhibits recA -dependent recombination. Expand
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  • X. Bi, L. Liu
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1996
TLDR
It is shown that inverted repeats can mediate an efficient and recA-independent recombination event and the product of this recombination is not that of simple inversion between the inverted repeats, but almost exclusively an unusual head-to-head dimer with complex DNA rearrangement. Expand
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