ras transformation is associated with decreased expression of the brm/SNF2alpha ATPase from the mammalian SWI-SNF complex.

@article{Muchardt1998rasTI,
  title={ras transformation is associated with decreased expression of the brm/SNF2alpha ATPase from the mammalian SWI-SNF complex.},
  author={Christian Muchardt and Brigitte Bourachot and Jos{\'e} Cano Reyes and M. Yaniv},
  journal={The EMBO journal},
  year={1998},
  volume={17 1},
  pages={223-31}
}
The brm and BRG-1 proteins are mutually exclusive subunits of the mammalian SWI-SNF complex. Within this complex, they provide the ATPase activity necessary for transcriptional regulation by nucleosome disruption. Both proteins were recently found to interact with the p105Rb tumor suppressor gene product, suggesting a role for the mammalian SWI-SNF complex in the control of cell growth. We show here that the expression of brm, but not BRG-1, is negatively regulated by mitogenic stimulation, and… CONTINUE READING

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Liganddependent interaction between the estrogen receptor and the human homologues of SWI2/SNF2

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