ras oncogene p21 expression in hepatocellular carcinoma.

  title={ras oncogene p21 expression in hepatocellular carcinoma.},
  author={Jaishree Jagirdar and Akitaka Nonomura and Jayshree Patil and Ann Thor and Fiorenzo Paronetto},
  journal={Journal of experimental pathology},
  volume={4 1},
Aberrant proto-oncogene expression has been implicated in hepatic cell proliferation, transformation and carcinogenesis using a rat model. To investigate the role of ras p21 product expression in human hepatocellular carcinoma (HCC), we have localized ras p21 in formalin fixed, paraffin-embedded normal and abnormal livers utilizing the avidin-biotin peroxidase method and a monoclonal antibody to ras-gene product p21. A semi-quantitative estimate of p21 expression was performed by serial… CONTINUE READING