ras-family gene mutations in neoplasia of the ampulla of Vater.

  title={ras-family gene mutations in neoplasia of the ampulla of Vater.},
  author={Aldo Scarpa and Giuseppe Zamboni and Alberto Achille and Paola Capelli and Giuseppe Salvatore Bogina and Calogero Iacono and Gabriella Serio and Roberto S. Accolla},
  journal={International journal of cancer},
  volume={59 1},
Mutations in the first and second exons of Ha-, Ki- and N-ras oncogenes were investigated in 17 epithelial tumors of the ampulla of Vater by single-strand conformation polymorphism analysis and direct sequencing of DNA fragments amplified by polymerase chain reaction. The panel included 12 intestinal-type adenocarcinomas, 3 villous adenomas, 1 papillary carcinoma and 1 neuroendocrine carcinoma. Six cases (35%) contained ras mutations, affecting codon 12 of Ki-ras in 2 adenomas and 3 carcinomas… CONTINUE READING
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