ras and human tumors.

  title={ras and human tumors.},
  author={Sjoerd Rodenhuis},
  journal={Seminars in cancer biology},
  volume={3 4},
Mutational activation of ras oncogenes is frequently encountered in human tumors. For unexplained reasons, K-ras mutations are predominantly found in pancreatic cancer, colorectal cancer and adeno-carcinoma of the lung, N-ras is predominantly found in a subset of acute leukemias and in myelodysplastic syndromes, while H-ras mutations are rare. In most tumors, ras mutations are not clearly associated with specific clinical or biological features, but in lung cancer, childhood lymphoblastic… CONTINUE READING