ramR mutations involved in efflux-mediated multidrug resistance in Salmonella enterica serovar Typhimurium.

@article{Abouzeed2008ramRMI,
  title={ramR mutations involved in efflux-mediated multidrug resistance in Salmonella enterica serovar Typhimurium.},
  author={Yousef M Abouzeed and Sylvie Baucheron and Axel 7 Cloeckaert},
  journal={Antimicrobial agents and chemotherapy},
  year={2008},
  volume={52 7},
  pages={2428-34}
}
In the sequenced genome of Salmonella enterica serovar Typhimurium strain LT2, an open reading frame (STM0580) coding for a putative regulatory protein of the TetR family is found upstream of the ramA gene. Overexpression of ramA results in increased expression of the AcrAB efflux pump and, consequently, multidrug resistance (MDR) in several bacterial species. The inactivation of the putative regulatory protein gene upstream of ramA in a susceptible serovar Typhimurium strain resulted in an MDR… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 56 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 34 references

dence for active efflux as the primary mechanism of resistance to ciprofloxacin in Salmonella enterica serovar Typhimurium

  • E. Hernandez-Urzua
  • Antimicrob . Agents Che - mother .
  • 2007

Similar Papers

Loading similar papers…