rBTI induces apoptosis in human solid tumor cell lines by loss in mitochondrial transmembrane potential and caspase activation.

@article{Li2009rBTIIA,
  title={rBTI induces apoptosis in human solid tumor cell lines by loss in mitochondrial transmembrane potential and caspase activation.},
  author={Yu-ying Li and Zheng Zhang and Zhuan-hua Wang and Hong-Wei Wang and Li Zhang and Lei Zhu},
  journal={Toxicology letters},
  year={2009},
  volume={189 2},
  pages={166-75}
}
The molecular mechanisms and the possible effects of a recombinant buckwheat trypsin inhibitor (rBTI) on the induction of apoptosis in the human solid tumor cells (EC9706, HepG2 and HeLa) were investigated. An MTT assay showed that rBTI could specifically inhibit the growth of solid tumor cells in a dose- and time-dependent manner. Analysis by flow cytometry indicated that the apoptosis of several tumor cells increased after treatment with rBTI in range of 6.25-50microg/ml. DNA electrophoresis… CONTINUE READING

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