rBAT-b(0,+)AT heterodimer is the main apical reabsorption system for cystine in the kidney.

@article{Fernndez2002rBATb0ATHI,
  title={rBAT-b(0,+)AT heterodimer is the main apical reabsorption system for cystine in the kidney.},
  author={Esperanza Romero Fern{\'a}ndez and Montserrat Carrascal and Ferran Rousaud and Joaquin Abian and Antonio Zorzano and Manuel Palac{\'i}n and Josep Chillar{\'o}n},
  journal={American journal of physiology. Renal physiology},
  year={2002},
  volume={283 3},
  pages={F540-8}
}
Mutations in the rBAT and b(0,+)AT genes cause type I and non-type I cystinuria, respectively. The disulfide-linked rBAT-b(0,+)AT heterodimer mediates high-affinity transport of cystine and dibasic amino acids (b(0,+)-like activity) in heterologous cell systems. However, the significance of this heterodimer for cystine reabsorption is unknown, as direct evidence for such a complex in vivo is lacking and the expression patterns of rBAT and b(0,+)AT along the proximal tubule are opposite. We… CONTINUE READING