ptk7 mutant zebrafish models of congenital and idiopathic scoliosis implicate dysregulated Wnt signalling in disease

@inproceedings{Hayes2014ptk7MZ,
  title={ptk7 mutant zebrafish models of congenital and idiopathic scoliosis implicate dysregulated Wnt signalling in disease},
  author={Madeline Hayes and Xiaochong Gao and Lisa X. Yu and Nandina Paria and R. Mark Henkelman and Carol A. Wise and Brian Ciruna},
  booktitle={Nature communications},
  year={2014}
}
Scoliosis is a complex genetic disorder of the musculoskeletal system, characterized by three-dimensional rotation of the spine. Curvatures caused by malformed vertebrae (congenital scoliosis (CS)) are apparent at birth. Spinal curvatures with no underlying vertebral abnormality (idiopathic scoliosis (IS)) most commonly manifest during adolescence. The genetic and biological mechanisms responsible for IS remain poorly understood due largely to limited experimental models. Here we describe… CONTINUE READING
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