prx-1 functions cooperatively with another paired-related homeobox gene, prx-2, to maintain cell fates within the craniofacial mesenchyme.

@article{Lu1999prx1FC,
  title={prx-1 functions cooperatively with another paired-related homeobox gene, prx-2, to maintain cell fates within the craniofacial mesenchyme.},
  author={Mei Fang Lu and Hsinlin T Cheng and Michael J. Kern and S. Steven Potter and Bao Nguyen Tran and Thomas G. H. Diekwisch and James F. Martin},
  journal={Development},
  year={1999},
  volume={126 3},
  pages={495-504}
}
The paired-related homeobox gene, prx-1, is expressed in the postmigratory cranial mesenchyme of all facial prominences and is required for the formation of proximal first arch derivatives. We introduced lacZ into the prx-1 locus to study the developmental fate of cells destined to express prx-1 in the prx-1 mutant background. lacZ was normally expressed in prx-1(neo); prx-1(lacZ )mutant craniofacial mesenchyme up until 11.5 d.p.c. At later time points, lacZ expression was lost from structures… CONTINUE READING
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